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Who discovered Prontosil in 1932?
Gerhard Domagk, (born October 30, 1895, Lagow, Brandenburg, Germany—died April 24, 1964, Burgberg, near Königsfeld, West Germany [now in Germany]), German bacteriologist and pathologist who was awarded the 1939 Nobel Prize for Physiology or Medicine for his discovery (announced in 1932) of the antibacterial effects of …
When was sulfanilamide discovered?
Sulfanilamide was first prepared in 1908 by the Austrian chemist Paul Josef Jakob Gelmo (1879–1961) as part of his dissertation for a doctoral degree from the Technische Hochschule of Vienna. It was patented in 1909.
How was sulfonamide discovered?
The antibacterial effects of sulfonamides were first observed in 1932, when German bacteriologist and pathologist Gerhard Domagk noted the effects of the red dye Prontosil on Streptococcus infections in mice.
What compound did Gerhard Domagk discover at IG Farben?
Despite the wartime transgressions of the company, IG Farben spawned a new era in medicine, and Gerhard Domagk was awarded the Nobel Prize in 1939 “for the discovery of the antibacterial effects of prontosil” [29].
Who was domagk first human trial?
Gerhard Domagk. Prontosil was the first drug to successfully treat bacterial infections and the first of many sulfa drugs—forerunners of antibiotics. This achievement earned its creator a Nobel Prize, which the German authorities forced him to reject.
Is Prontosil still used?
Prontosil has been replaced in clinical use by newer sulfonamide drugs, including sulfanilamide, sulfathiazole, sulfamethoxazole, and others.
What is Gerhard Domagk known for?
Prontosil was the first drug to successfully treat bacterial infections and the first of many sulfa drugs—forerunners of antibiotics. This achievement earned its creator a Nobel Prize, which the German authorities forced him to reject.
When did Alexander Fleming discover penicillin?
He named the ‘mould juice’ penicillin. Later, he would say: “When I woke up just after dawn on September 28, 1928, I certainly didn’t plan to revolutionize all medicine by discovering the world’s first antibiotic, or bacteria killer.
What did Gerhard Domagk do?
What did domagk discover?
The challenge was long thought to be impossible, but in 1932 Gerhard Domagk and his colleagues demonstrated in mice experiments that sulfonamides could be used to counteract bacteria that cause blood poisoning. The discovery became the basis for a number of sulfa drugs – the first type of antibiotic.
How did domagk discover Prontosil?
The Discovery of Prontosil Among the hundreds of chemical compounds prepared by Mietzsch and Klarer for Domagk to test were some related to the azo dyes. Among the early patients was Domagk’s own six-year-old daughter, Hildegard, who had contracted a severe streptococcal infection from an unsterilized needle.
Where did Gerhard Domagk go to Grammar School?
Burgberg, Germany, 24 April 1964) medicine, chemistry, pharmacology. Domagk, the son of a teacher, decided to study medicine while still at a scientifically oriented grammar school in Liegnitz (now Legnica).
How did Gerhard Domagk get his Nobel Prize?
Under the grip of Hitler and the Nazi Party, German citizens were forbidden to accept the Nobel Prize. After Domagk accepted the prize, he was arrested by the Gestapo and forced to send a letter rejecting it. Although Domagk was able to receive his prize medal in 1947, the prize money had long since been redistributed.
What kind of cancer did Gerhard Domagk have?
Domagk became a Foreign Member of the Royal Society in 1959; his short biography was published by the Royal Society in 1964. He changed his focus to tuberculosis and chemotherapy against cancer. He continued to live and work in Wuppertal. Domagk died from a appendicitis in Burgberg near Königsfeld, Schwarzwald.
What did Gerhard Domagk do after World War 1?
Domagk studied medicine at the University of Kiel, but volunteered to serve as a soldier in World War I, where he was wounded in December 1914, working the rest of the war as a medic. After the war, he finished his studies, and worked at the University of Greifswald, where he researched infections caused by bacteria .