Why is B6 given with isoniazid?

Why is B6 given with isoniazid?

Isoniazid can interfere with the activity of vitamin B6. Vitamin B6 supplementation is recommended, especially in people with poor nutritional status, to prevent development of isoniazid-induced peripheral neuritis (inflamed nerves). One case is reported in which injectable vitamin B6 reversed isoniazid-induced coma.

What is the relationship between pyridoxine and isoniazid?

A 10 mg. dose of pyridoxine for each 100 mg. of isoniazid appears adequate to prevent both clinical and potential subclinical manifestations of pyridoxine deficiency. The administration of pyridoxine does not interfere with the antituberculous action of isoniazid.

Why is pyridoxine used with TB meds?

Pyridoxine is another name for vitamin B6. Vitamin B6 is used to prevent numbing and tingling of the hands or feet sometimes caused by isoniazid or other TB medicines.

Why anti TB drugs are given in combination?

Treating a tuberculosis patient with a monotherapy of rifampicin rapidly leads to resistance to the drug even if it is given for short periods only. In combination drugs, the presence of isoniazid reduces the probability for the survival of rifampicin-resistant mutants.

How does pyridoxine work in isoniazid toxicity?

References. Isoniazid causes a depletion of pyridoxal-5′-phosphate (the active form of pyridoxine) by inhibiting pyridoxine phosphokinase. This inhibition leads to decreased gamma-aminobutyric acid (GABA) synthesis and acute toxicity that is manifested as seizures.

How does isoniazid cause hepatotoxicity?

Chronic INH hepatotoxicity results in the induction of hepatocyte apoptosis, with associated disruption of mitochondrial membrane potential and DNA strand breaks. The most likely biochemical mechanism is that the metabolism of INH produces reactive metabolites that bind and damage cellular macromolecules in the liver.

What is anti tuberculosis drugs are always prescribed in combination?

Rifampicin should always be given in combination with other effective antimycobacterial agents. It is also available for intravenous administration in critically ill patients (1). Adults: 10 mg/kg (8–12 mg/kg) daily or 3 times weekly, maximum 600 mg.

Why do we use combination therapy?

Uses. Conditions treated with combination therapy include tuberculosis, leprosy, cancer, malaria, and HIV/AIDS. One major benefit of combination therapies is that they reduce development of drug resistance since a pathogen or tumor is less likely to have resistance to multiple drugs simultaneously.

How is isoniazid toxicity treated?

It is concluded that diazepam in combination with pyridoxine is the treatment of choice for the management of convulsions associated with isoniazid toxicity. Pyridoxine should be administered intravenously in amounts equal to the estimated quantity of isoniazid ingested, even if seizures have not occurred.

What are the therapeutic uses of pyridoxine?

Pyridoxine is used to treat or prevent vitamin B6 deficiency. It is also used to treat a certain type of anemia (lack of red blood cells). Pyridoxine injection is also used to treat some types of seizure in babies. Pyridoxine taken by mouth (oral) is available without a prescription.

Why is vitamin B6 given with isoniazid?

Supplementation of vitamin B6 (pyridoxine) during treatment with isoniazid (inh) is necessary in some patients to prevent the development of peripheral neuropathy and deficiencies induced by vitamins and people with a risk factor, such as pregnancy, lactation, infection by HIV, alcoholism, diabetes,…

Can I overdose on pyridoxine?

It is possible to overdose on vitamin B6 (pyridoxine). Vitamin B6 is present in a variety of foods, which is how most people get their daily requirement. B6 may also be present in other combination B vitamins or multivitamins. Taking any of these in combination with pyridoxine may lead to overdose.

Is pyridoxine hydrochloride vegan?

This vegetarian support formula is a vegan staple. yeast, niacin (b3), thiamin hydrochloride (b1), riboflavin (b2), pyridoxine hydrochloride (b6), vitamin b12.