Who is most likely to get Ehlers-Danlos syndrome?

Who is most likely to get Ehlers-Danlos syndrome?

Most are rare e.g., 1 in 40,000 – 200,000 and some are ultrarare i.e., less than 1 in a million people. Individuals of all racial and ethnic backgrounds are affected by EDS which can present with complications from birth and progress over time.

What are the specific symptoms of Ehlers-Danlos syndrome?

Main types of Ehlers-Danlos syndromes (EDS)

• joint hypermobility.
• loose, unstable joints that dislocate easily.
• joint pain and clicking joints.
• extreme tiredness (fatigue)
• skin that bruises easily.
• digestive problems, such as heartburn and constipation.
• dizziness and an increased heart rate after standing up.

Does Ehlers-Danlos shorten life expectancy?

Patients with the classical and hypermobility forms of Ehlers-Danlos syndrome have a normal life expectancy. About 80% of patients with vascular Ehlers-Danlos syndrome will experience a major health event by age 40 and the life expectancy is shortened, with an average age of death of 48 years.

What triggers EDS?

Causes. EDS happens when your body doesn’t make a protein called collagen in the right way. Collagen helps form the connections that hold your body’s bones, skin, and organs together. If there’s a problem with it, those structures can be weak and more likely to have problems.

What percent of the population has Ehlers-Danlos syndrome?

The combined prevalence of all types of Ehlers-Danlos syndrome appears to be at least 1 in 5,000 individuals worldwide. The hypermobile and classical forms are most common; the hypermobile type may affect as many as 1 in 5,000 to 20,000 people, while the classical type probably occurs in 1 in 20,000 to 40,000 people.

Is Ehlers-Danlos syndrome life threatening?

Ehlers-Danlos syndrome is a group of disorders that affect connective tissues supporting the skin, bones, blood vessels, and many other organs and tissues. Defects in connective tissues cause the signs and symptoms of these conditions, which range from mildly loose joints to life-threatening complications.

Is Ehlers-Danlos a terminal illness?

Vascular Ehlers-Danlos syndrome is a rare, life-threatening, autosomal dominant variant of EDS, resulting from mutations in COL3A1 gene. Affected individuals are prone to serious and potentially fatal complications, especially vascular, intestinal, and uterine ruptures.

How do you explain Ehlers-Danlos syndrome?

Ehlers-Danlos syndrome (EDS) is a disease that weakens the connective tissues of your body. These are things like tendons and ligaments that hold parts of your body together. EDS can make your joints loose and your skin thin and easily bruised. It also can weaken blood vessels and organs.

What age is Ehlers-Danlos syndrome diagnosed?

The age at first diagnosis peaked in the age group 5–9 years for men and 15–19 years for women (see figure 2). There was a significant difference of 8.5 years in the mean age of diagnosis between men and women (95% CI: 7.70 to 9.22): 9.6 years in EDS (95% CI: 6.85 to 12.31) and 8.3 years in JHS (95% CI: 7.58 to 9.11).

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